What role does alpha-ketoglutarate play in the Cahill Cycle?
Click to see answer
It accepts NH3 to form glutamate.
Click to see question
What role does alpha-ketoglutarate play in the Cahill Cycle?
It accepts NH3 to form glutamate.
What occurs in the liver during the Cahill Cycle?
Alanine is converted back to glutamate and pyruvate, and pyruvate is then converted to glucose via gluconeogenesis.
What is the function of alanine transaminase (ALT) in skeletal muscle?
ALT transfers an amino group from glutamate to pyruvate, producing alanine and alpha-ketoglutarate.
What is the Cori Cycle also known as?
The lactic acid cycle.
What happens to amino acids in skeletal muscle during the Cahill Cycle?
They are deaminated to form alpha-ketoacids and NH3.
What is the Cahill Cycle also known as?
The glucose-alanine cycle.
What process does the Cahill Cycle facilitate?
It shuttles amino and carbon groups from skeletal muscle to the liver for deamination and gluconeogenesis.
What enzyme converts pyruvate to lactate in skeletal muscle?
Lactate dehydrogenase (LDH).
What cycle does ammonia enter to be excreted?
The urea cycle.
How is ammonia transported from skeletal muscle to the liver?
In a non-toxic form as alanine.
What is the final product transported back to skeletal muscle in both the Cahill and Cori cycles?
Glucose.
What does the Cori Cycle transport from skeletal muscle to the liver?
Lactate.
What does glutamate dehydrogenase catalyze?
The oxidative deamination of glutamate to alpha-ketoglutarate and NH3.
What happens to lactate in the liver during the Cori Cycle?
It is converted back to pyruvate and then to glucose via gluconeogenesis.
