The distribution of a given drug within the body.
Vd = amount of drug administered ÷ concentration of drug in plasma.
42 L.
Local damage to tissues.
Heavy metals and tetracycline.
Muscle, liver, and kidneys.
Severe organ damage.
Inhalation anesthetics and toxic substances.
Lipid solubility.
They bind to drugs, affecting their availability and distribution.
Adipose tissue.
Long-term storage.
A drug’s distribution by comparing it with the total amount of body water in a healthy person.
Blood-brain barrier.
Cell membranes, organelles, and proteins.
It can lead to ineffective treatment as the drug may not reach the target site.
Bone.
Increased blood flow enhances drug delivery to tissues.
It can soak up the drug and prevent it from reaching the target site.
