What does the volume of distribution (Vd) describe?
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The distribution of a given drug within the body.
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What does the volume of distribution (Vd) describe?
The distribution of a given drug within the body.
How is Vd calculated?
Vd = amount of drug administered ÷ concentration of drug in plasma.
If 420 mg of a drug is administered and the plasma concentration is 0.01 mg/mL, what is the Vd?
42 L.
What is a potential local consequence of drug storage?
Local damage to tissues.
What type of substances can be stored in bone?
Heavy metals and tetracycline.
What organs are involved in drug storage besides adipose tissue?
Muscle, liver, and kidneys.
What severe consequence can result from improper drug storage?
Severe organ damage.
Which substances are commonly stored in adipose tissue?
Inhalation anesthetics and toxic substances.
What type of solubility allows drugs to easily cross cell membranes?
Lipid solubility.
What role do plasma proteins play in drug distribution?
They bind to drugs, affecting their availability and distribution.
What is the primary storage site for lipid-soluble substances?
Adipose tissue.
What is a characteristic of drug storage in bone?
Long-term storage.
What does Vd help estimate?
A drug’s distribution by comparing it with the total amount of body water in a healthy person.
What is the barrier that restricts drug entry into the brain?
Blood-brain barrier.
What are subcellular components that drugs can bind to?
Cell membranes, organelles, and proteins.
What can occur due to the redistribution of drugs?
It can lead to ineffective treatment as the drug may not reach the target site.
Which organ is involved in the storage of antimalarial drugs?
Bone.
How does blood flow affect drug distribution?
Increased blood flow enhances drug delivery to tissues.
How can drug storage affect drug efficacy?
It can soak up the drug and prevent it from reaching the target site.
