What is the primary storage site for lipid-soluble substances?
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Adipose tissue.
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What is the primary storage site for lipid-soluble substances?
Adipose tissue.
Which substances are commonly stored in adipose tissue?
Inhalation anesthetics and toxic substances.
What does the volume of distribution (Vd) describe?
The distribution of a given drug within the body.
What type of substances can be stored in bone?
Heavy metals and tetracycline.
How is Vd calculated?
Vd = amount of drug administered ÷ concentration of drug in plasma.
What is a characteristic of drug storage in bone?
Long-term storage.
What does Vd help estimate?
A drug’s distribution by comparing it with the total amount of body water in a healthy person.
What type of solubility allows drugs to easily cross cell membranes?
Lipid solubility.
Which organ is involved in the storage of antimalarial drugs?
Bone.
If 420 mg of a drug is administered and the plasma concentration is 0.01 mg/mL, what is the Vd?
42 L.
What is the barrier that restricts drug entry into the brain?
Blood-brain barrier.
What organs are involved in drug storage besides adipose tissue?
Muscle, liver, and kidneys.
How does blood flow affect drug distribution?
Increased blood flow enhances drug delivery to tissues.
What role do plasma proteins play in drug distribution?
They bind to drugs, affecting their availability and distribution.
What is a potential local consequence of drug storage?
Local damage to tissues.
What are subcellular components that drugs can bind to?
Cell membranes, organelles, and proteins.
What can occur due to the redistribution of drugs?
It can lead to ineffective treatment as the drug may not reach the target site.
How can drug storage affect drug efficacy?
It can soak up the drug and prevent it from reaching the target site.
What severe consequence can result from improper drug storage?
Severe organ damage.
