Question 1

In Limbic-Predominant Encephalopathy, there are usually no other coexistent ___.

Accepted Answer

antibodies

Question 2

CASPR2 antibodies are linked to ___, a condition where the immune system mistakenly attacks the brain.

Accepted Answer

autoimmune encephalitis

Question 3

CASPR2 antibody disease primarily affects older males, typically in their ___ and ___.

Accepted Answer

sixties, seventies

Question 4

___ shows encephalopathy in patients with CASPR2 antibody disease.

Accepted Answer

EEG

Question 5

Morvan Syndrome symptoms include severe autonomic dysfunction, ___, peripheral nerve hyperexcitability, and psychiatric symptoms.

Accepted Answer

insomnia

Question 6

In diagnostic investigations for CASPR2 antibody disease, ___ and ___ are often normal.

Accepted Answer

CSF, MRI

Question 7

The male-to-female ratio of CASPR2 antibody disease is about ___:___.

Accepted Answer

9:1

Question 8

Needle EMG detects peripheral nerve ___, which is a specific feature of CASPR2 antibody disease.

Accepted Answer

hyperexcitability

Question 9

Immunotherapies are more effective in patients with ___ antibodies compared to those with CASPR2 antibodies.

Accepted Answer

LGI1

Question 10

The disease typically develops over several ___, which can overlap with more rapid neurodegenerative conditions like Creutzfeldt-Jakob disease.

Accepted Answer

months

Question 11

Neuropathic pain in Morvan syndrome is possibly due to small fiber ___.

Accepted Answer

neuropathy

Question 12

Higher titers in ___ help reduce false positives in antibody testing for CASPR2 antibody disease.

Accepted Answer

CSF

Question 13

Limbic-Predominant Encephalopathy symptoms include ___, ___, and ___.

Accepted Answer

disorientation, amnesia, seizures

Question 14

Approximately ___% of patients with Morvan Syndrome have a thymoma.

Accepted Answer

25

Question 15

Movement disorders associated with CASPR2 antibody disease include ataxia, myoclonus, tremor, paroxysmal ataxia, and orthostatic leg ___.

Accepted Answer

myoclonus