What are some movement disorders associated with CASPR2 antibody disease?
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Ataxia, myoclonus, tremor, paroxysmal ataxia, and orthostatic leg myoclonus.
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What are some movement disorders associated with CASPR2 antibody disease?
Ataxia, myoclonus, tremor, paroxysmal ataxia, and orthostatic leg myoclonus.
How does CASPR2 antibody disease typically develop?
The disease typically develops over several months.
What is CASPR2 antibody disease?
CASPR2 antibody disease is linked to autoimmune encephalitis, where the immune system mistakenly attacks the brain.
What type of pain is common in Morvan syndrome and what might cause it?
Neuropathic pain, possibly due to small fiber neuropathy.
What percentage of Morvan syndrome patients have a thymoma?
Approximately 25%.
Are there usually other coexistent antibodies in limbic-predominant encephalopathy?
No, usually there are no other coexistent antibodies.
What does needle EMG detect in CASPR2 antibody disease?
Needle EMG detects peripheral nerve hyperexcitability.
What is the rate of underlying tumors in limbic-predominant encephalopathy?
Low rates of underlying tumors.
Why is antibody testing in CSF important for CASPR2 antibody disease?
Higher titers in CSF help reduce false positives.
What are the main symptoms of Morvan syndrome?
Severe autonomic dysfunction, insomnia, peripheral nerve hyperexcitability, and psychiatric symptoms.
Which patients respond better to immunotherapies, those with LGI1 antibodies or CASPR2 antibodies?
Patients with LGI1 antibodies respond better to immunotherapies.
What are the main symptoms of limbic-predominant encephalopathy?
Disorientation, amnesia, and seizures.
What does EEG typically show in CASPR2 antibody disease?
EEG shows encephalopathy.
Which demographic is primarily affected by CASPR2 antibody disease?
Older males, typically in their sixties and seventies, with a male-to-female ratio of about 9:1.
Which antibodies are often coexistent in Morvan syndrome?
LGI1 antibodies.
What are the typical findings in CSF and MRI for CASPR2 antibody disease?
CSF and MRI are often normal.
