What significant changes occur during the transition from intrauterine to extrauterine life?
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Critical changes in the cardiovascular and respiratory systems.
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What significant changes occur during the transition from intrauterine to extrauterine life?
Critical changes in the cardiovascular and respiratory systems.
What marks the beginning of cleavage in human development?
The inward movement of the fertilized oocyte (ovum).
What is the term for the period of extrauterine life after birth?
Infancy.
What marks the beginning of human development?
Fertilization.
What is the significance of understanding normal development in relation to birth defects?
It helps in the understanding and correction of most defects and dispels parental guilt feelings.
What did ancient Egyptians believe about the soul and the infant?
They believed the soul entered the infant at birth through the placenta.
What happens to an infant's body during the first year?
Total length increases by approximately one half and weight usually triples.
What significant contribution did Leonardo da Vinci make to embryology?
He made accurate drawings of dissections of pregnant uteri containing fetuses.
What does Slack JMW's 'Essential developmental biology' cover?
Fundamental concepts in developmental biology.
Why is knowledge of human development significant for pediatricians?
Because some patients have birth defects resulting from maldevelopment.
What ethical issues are discussed by Hovatta O and colleagues?
European scientific, ethical, and legal issues on human stem cell research.
What is a neonate?
An infant age 1 month or younger.
What significant contribution did O’Rahilly R make to embryology?
Described developmental stages in human embryos.
In which part of the embryo does the vertebral column develop?
In the dorsal part of the embryo.
What misconception about embryos persisted during the Middle Ages?
The theory that embryos were derived from menstrual blood and semen, often depicted as fully developed infants in the womb.
What is the median section in anatomical terms?
A vertical plane that divides the body into right and left halves.
What did Caspar Friedrich Wolff propose in 1759?
The layer concept, stating that development results from growth and differentiation of specialized cells.
What is the significance of Hans Spemann in embryology?
He is known for his work on inducers and 'organizers' in experimental embryology.
What does the Sanskrit treatise Garbha Upanishad describe?
It describes ancient views concerning the development of the embryo.
What is the period between infancy and puberty called?
Childhood.
What did Girolamo Fabricius contribute to embryology?
He wrote major treatises, including 'De Formato Foetu', which contained illustrations of embryos at different stages.
What did Karl Ernst von Baer contribute to embryology in 1827?
He described the oocyte and observed cleaving zygotes and blastocysts.
What historical aspect does Hopwood N explore?
Normal plates, tables, and stages in vertebrate embryology.
Who wrote 'On the Formation of the Foetus'?
Claudius Galen.
What does the term 'anatomical position' refer to?
A standard position of the body used as a reference in anatomy.
What is puberty?
The period when humans become functionally capable of reproduction.
What are the two important embryologic concepts formulated by von Baer?
Corresponding stages of embryonic development and that general characteristics precede specific ones.
Who is considered the father of medical genetics?
Sir Archibald Garrod.
What are the two main prenatal periods of human development?
Embryonic and fetal periods.
What is the critical period for development during pregnancy?
The first trimester (13 weeks).
How does knowledge of common congenital birth defects benefit healthcare professionals?
It allows them to approach unusual situations with confidence rather than surprise.
What was the significance of William Harvey's book 'De Generatione Animalium'?
It marked the beginning of the embryologic revolution, proposing that male sperm metamorphosed into an egg-like substance.
What is teratology?
The division of embryology and pathology that deals with abnormal development and birth defects.
What is the focus of the work by Daughtry B1 and Mitalipov S?
Parthenote stem cells for regenerative medicine.
What is the importance of understanding physiologic changes during the neonatal period?
It is essential for helping fetuses and neonates in distress.
What does the 'Color atlas of clinical embryology' provide?
Visual references for clinical embryology.
What misconception did Johan Ham van Arnheim and Anton van Leeuwenhoek have about sperm?
They thought sperm contained a miniature preformed human being.
What did Aristotle believe about the development of the embryo?
He believed it developed from a formless mass, arising from menstrual blood after activation by male semen.
What did Samuel-el-Yehudi describe in the second century AD?
He described six stages in the formation of the embryo.
What does the Quran state about human development?
It states that human beings are produced from a mixture of secretions from the male and female.
What is indicated by the migration of mesenchymal cells?
The development of the trilaminar embryo.
What terms are used to describe the front and back of the body?
Anterior (ventral) and posterior (dorsal).
What are pharyngeal arches?
Structures that contribute to the formation of the face and neck during embryonic development.
What changes occur in the face during the fetal period?
The face has a more developed profile and the chin grows compared to earlier stages.
What are the eight late metabolic fields discovered in embryology?
Condensation, contusion, distussion, dilation, retension, detraction, corrosion, and parathelial loosening.
What significant changes occur during the fetal period?
Differentiation and growth of tissues and organs.
What is the anatomical position?
The body is erect, with upper limbs by the sides and palms directed anteriorly.
What is clinically oriented embryology?
It refers to the study of embryos, focusing on prenatal development.
Where does the sternum develop in the embryo?
In the ventral part of the embryo.
What environmental factor was shown to adversely affect human embryo development in 1941?
Rubella virus infection in early pregnancy.
What is the fertilized oocyte called?
Zygote.
What is the focus of Chapter 1 in the context of human development?
Clinically oriented problems.
What is the focus of Murillo-Gonzalés J's work on embryology?
A synthesis of classical, experimental, and molecular perspectives.
What does Nusslein-Volhard C's book discuss?
How genes drive development.
What is the significance of the embryonic period?
It is when most visible advances in development occur.
What was demonstrated by Jérôme Jean Louis Marie Lejeune in 1959?
Infants with Down syndrome have 47 chromosomes instead of the usual 46.
What is the significance of the genital tubercle?
It is the precursor to external genitalia in the developing embryo.
Who discovered sex chromatin in 1949?
Dr. Murray Barr and his graduate student Ewart (Mike) Bertram.
What concerns are associated with human cloning?
Social, ethical, and legal implications, as well as potential birth defects.
During which weeks do the most visible advances in development occur?
Third to eighth weeks (embryonic period).
What are the postnatal periods of human development?
Neonatal, infancy, childhood, and adolescence.
What structures begin to develop during Stage 16?
Oral and nasal cavities become confluent.
What are the main considerations for human pluripotent stem cell culture?
Maintenance, expansion, and therapeutics.
What is the significance of the neural groove?
It is a precursor to the neural tube, which will develop into the central nervous system.
What are some embryologic topics of special interest to obstetricians?
Oocyte and sperm transport, ovulation, fertilization, implantation, and fetal-maternal relations.
What cloning technique was used to create the first mammal, Dolly?
Somatic cell nuclear transfer.
What is the cranial direction in anatomical terms?
Towards the head or upper part of the body.
What revolutionary technique in human reproduction was pioneered by Robert G. Edwards and Patrick Steptoe?
In vitro fertilization.
What is the primitive streak?
A structure that forms during embryonic development, marking the beginning of gastrulation.
At what stage does the heart begin to beat?
Stage 14.
What is apoptosis?
Programmed cell death.
Who discovered the three germ layers of the embryo?
Heinrich Christian Pander.
What is the purpose of using descriptive terms in embryology?
To denote the position of one part relative to another or to the body as a whole.
What drug was linked to severe birth defects in the 1960s?
Thalidomide.
What did Wolff's observations lead to in terms of embryonic development?
The theory of epigenesis.
What did Charles Darwin emphasize in his book 'On the Origin of Species'?
The hereditary nature of variability among members of a species.
How long does embryonic development last?
It ends at stage 23, which occurs on day 56.
Who authored 'A history of embryology'?
Needham J.
Who reported the first observations on human chromosomes and in what year?
Felix von Winiwarter reported the first observations on human chromosomes in 1912.
What was the initially accepted number of chromosomes in human body cells before 1956?
48 chromosomes.
What occurs just before puberty?
A prepubertal growth spurt.
What do the terms cranial and caudal refer to in embryology?
Cranial refers to the head, and caudal refers to the tail.
What does the term 'digital rays' refer to?
The early formation of fingers and toes in the developing embryo.
What does 'caudal' refer to in anatomical terminology?
Towards the tail or lower part of the body.
What does CRL stand for in embryonic measurements?
Crown-rump length.
What happens to development after birth?
Other changes occur in addition to growth, such as development of teeth and female breasts.
Who is regarded as the father of medicine and contributed to embryology?
Hippocrates of Cos.
What is the subject of Pinto-Correia C's book?
The relationship between egg, sperm, and preformation.
What major breakthrough in genetics occurred in 1953?
James Watson and Francis Crick deciphered the molecular structure of DNA.
What is the median plane?
An imaginary vertical plane that divides the body into right and left halves.
What theory did Matthias Schleiden and Theodor Schwann formulate in 1839?
The cell theory, stating that the body is composed of cells and cell products.
What are metabolic fields in human embryology?
Regions where specific tissues differentiate from mesenchyme or epithelium.
What did Marcello Malpighi observe in 1675?
Early embryos in what he believed were unfertilized hen's eggs.
What did Lazzaro Spallanzani demonstrate in 1775?
Both the oocyte and sperm are necessary for initiating the development of a new individual.
What significant discovery did Joe Hin Tjio and Albert Levan make in 1956?
They reported finding only 46 chromosomes in embryonic cells.
What significant studies did Etienne and Isidore Saint Hilaire conduct in 1818?
They studied abnormal development and initiated the science of teratology.
What is the significance of the term 'pluripotential' in relation to human embryonic stem cells?
It indicates the ability to differentiate into specialized cell types.
What does the term 'sagittal plane' refer to?
A plane that divides the body into right and left sections.
What technique did Keith L. Moore develop related to sex chromatin?
A buccal smear sex chromatin test used clinically.
What initiates human development?
Fertilization of an oocyte by a sperm.