In which condition is the 'a' wave absent?
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Atrial fibrillation.
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In which condition is the 'a' wave absent?
Atrial fibrillation.
What is defined as having bowel movements fewer than three times per week?
Constipation.
What visual aids are referenced in the introduction on clinical examination?
Figs 1.13A to D.
What does a dry tongue suggest in a clinical examination?
Dehydration or shock.
What condition is indicated by splinter hemorrhages in the nailbed?
Bacterial endocarditis and bleeding disorders.
What are some causes of localized edema?
Cellulitis, lymphatic causes, venous diseases, pretibial myxoedema of thyrotoxicosis.
What are the grades of constipation?
0: none; 1: needs diet modification; 2: needs laxatives; 3: needs manual evacuation or enema; 4: due to obstruction.
What causes an ingrowing toenail?
Irregular edge of the nail growing beneath the lateral nail fold due to improper trimming.
What is the characteristic facial appearance in Cushing’s syndrome?
Moon face.
What does Terry's sign indicate?
Hypo-albuminaemia, causing whitening of the nailbed.
What is leukoplakia?
A whitish opaque thickened epithelium often associated with superficial glossitis.
What is the typical presentation of pulmonary edema in left ventricular failure (LVF)?
Dyspnea, basal crepitations, and cough.
What is hiccup and what are its common causes?
Spasmodic contraction of the diaphragm, commonly idiopathic or post-operative due to increased abdominal pressure.
What is an example of shifting pain?
Pain of acute appendicitis starts at the umbilicus and shifts to the right iliac fossa.
What are the observed changes in the toe nails mentioned in the text?
Pallor and koilonychia.
What is pseudoclubbing and in which condition is it seen?
Pseudoclubbing is seen in hyperparathyroidism due to undue bone resorption.
In congestive cardiac failure (CCF), where does edema typically occur?
In the lower limbs and is more pronounced in the evening.
What condition is indicated by an inability to protrude the tongue?
Ankyloglossia (tongue tie) or advanced carcinoma infiltrating the genioglossus muscle.
What is onychogryphosis?
Heaping up of the nail and curling over the end of the toe due to trauma or old age.
What is an anacrotic wave pulse and in which condition is it felt?
An anacrotic wave pulse is a small wave in the upstroke felt in severe aortic stenosis.
How is weight loss graded?
Weight loss is graded as: < 5% (0), 5-10% (1), 10-20% (2), > 20% (3).
What does Schamroth’s sign indicate?
Disappearance of the diamond-shaped gap between nails when fingers are apposed.
What condition is characterized by the absence of urobilinogen in urine?
Obstructive jaundice.
What dietary habit is commonly associated with hypercarotinaemia?
A vegetarian diet with high consumption of raw carrots.
What is gigantism?
Height that is in excess of normal for age, typically more than 6.5 feet in adults.
What is jaundice?
Yellowish discoloration of skin and mucous membranes due to excess bilirubin.
What is the role of the sphygmomanometer in measuring blood pressure?
The sphygmomanometer, invented by Riva Rocci, is used to measure BP by exerting lateral pressure on the artery walls.
What is flatulence?
Frequent belching more than normal.
What is the normal range for body temperature?
36.7°C to 37.5°C (98°F to 99°F).
What angle indicates clubbing of the nails?
More than 180 degrees.
What is the term for generalized edema?
Anasarca.
What is oedema?
The collection of fluid in the interstitial spaces or soft tissues.
How is weight gain graded?
Weight gain is graded as: < 5% (0), 5-10% (1), 10-20% (2), > 20% (3).
What conditions can lead to weight gain?
Obesity, pregnancy, myxoedema, water retention, and Cushing’s syndrome.
What mechanisms can lead to fluid accumulation in interstitial spaces?
Increased capillary permeability, increased capillary pressure, decreased osmotic pressure, and lymphatic block.
What is the normal range of urinary urobilinogen?
100-200 mg/day.
What causes the 'c' wave in JVP?
Carotid artery impact into the jugular vein and right ventricular systole.
What does the 'x' wave in JVP represent?
Fall in right atrial pressure and atrial relaxation.
What is indicated by a giant 'v' wave in JVP?
Tricuspid regurgitation.
What is Kussmaul’s sign?
Paradoxical increase in jugular venous pressure during inspiration in constrictive pericarditis.
What are the grades of fatigue?
0 (none), 1 (fatigue over baseline), 2 (moderate fatigue), 3 (severe), 4 (bedridden).
What are the phases in blood pressure measurement?
Phase I: Tapping sound; Phase II: Softening sounds; Phase III: Sharper sounds; Phase IV: Muffling sounds; Phase V: Disappearance of sounds.
What are pustules?
Epidermal elevations containing pus, often due to bacterial infections.
What condition is illustrated by dilated veins in the chest wall?
Superior vena caval obstruction.
What is clubbing in relation to nails?
Bulbous enlargement of the soft parts of the terminal phalanges with transverse and longitudinal curving of the nails.
What deformity of the nail is associated with fungal infection or tuberculosis?
Onychia.
What is the minimum hemoglobin percentage required to cause cyanosis?
Hemoglobin should be present in the circulation; in severe anemia (Hb% below 5 gm%), cyanosis is not seen.
What are the two types of cyanosis observed?
Peripheral and central cyanosis.
What is the grading system for diarrhea?
1: increase < 4 times/day; 2: increase 4-6/day; 3: increase > 7/day or with incontinence; 4: needs intensive care with hemodynamic collapse.
What is Boerhaave’s syndrome?
A condition that occurs after esophageal rupture, leading to mediastinal emphysema, subcutaneous emphysema, shock, and toxicity.
What is a dicrotic pulse and when is it observed?
A dicrotic pulse is a twice beating pulse with an initial normal percussion wave of systole and a prominent dicrotic wave in diastole, seen in conditions like CCF and cardiac tamponade.
What causes central cyanosis?
Reduced oxygen saturation of arterial blood due to poor oxygenation in the lungs.
What are some conditions associated with wasting?
Starvation, severe gastroenteritis, tuberculosis, anorexia nervosa, diabetes mellitus, advanced carcinomas, and gastrointestinal malignancies.
What is the normal difference in blood pressure between the right arm and the left arm?
BP in the right arm is higher by up to 10 mm Hg.
What is bone crepitus?
A grating sensation elicited over fracture segments when two bone fragments are moved against each other.
What is anorexia?
Loss of appetite, which can be seen in conditions like anorexia nervosa and gastrointestinal cancers.
What are vesicles?
Small blisters containing clear or milk-like fluid, seen in chickenpox and herpes.
What is pyrexia of unknown origin (PUO)?
Fever more than 101°F lasting more than 3 weeks with no diagnosis after one week of investigation.
What is the direction of blood flow in superior vena caval obstruction?
From above downwards towards the lower abdomen and to the inferior vena cava.
What causes hypertrophy and clubbing of the terminal phalanx?
Dilatation of arteriovenous anastomosis stimulated by systemic circulation.
How is jaundice checked in a clinical examination?
By asking the patient to look down while the examiner pulls the upper eyelids upwards, and also checking the nasal tip, ear lobule, fingertips, and under surface of the tongue.
What angle is formed in clubbing between the nail and the skin?
Greater than 180°.
List some pulmonary causes of clubbing.
Carcinoma bronchus, lung abscess, bronchiectasis, tuberculosis with secondary infection.
What happens to bilirubin in obstructive and hepatic jaundice?
Bile pigment (bilirubin) is seen in the urine.
What should be examined in both hands and feet during a nail examination?
Change in color, splinter hemorrhage, clubbing, pallor, koilonychia, and other features.
What is crepitus in de Quervain’s tenosynovitis?
Crepitus felt at the junction of extensor pollicis brevis and abductor pollicis longus when the hand is opened and closed.
What does pulsus alternans indicate?
Pulsus alternans indicates alternate strong and weak beats due to alternate contractions of the cardiac muscle, seen in left ventricular failure and toxic myocarditis.
What is the effect of isometric contraction on diastolic blood pressure?
It will elevate the diastolic BP by 10%.
What types of crepitus can be felt in joint diseases?
Fine crepitations in chronic diseases, coarse irregular crepitations in osteoarthritis, and clicks due to loose bodies.
What does nutritional status assess?
The proportion of soft tissue structures in relation to bony structure.
What is the typical facial appearance in chronic renal failure?
A typical pale look.
What is hypotension?
Diminished BP with systolic pressure less than 90 mm Hg.
What is a common sign of iron deficiency anemia observed in nails?
Brittle, flat nails (platynychia) or spoon-shaped nails (koilonychia).
What causes the loss of the normal angle between the nail and the skin in clubbing?
Tissue hypertrophy beneath the nailbed.
What are the features of a neonate with cretinism?
Broad flat face, wide apart eyes, protruded tongue.
What is the role of glucuronyl transferase in bilirubin metabolism?
It conjugates bilirubin to bilirubin glucuronide, making it water-soluble for excretion.
What does the 'a' wave in JVP indicate?
Right atrial contraction.
What characterizes a pulsus bisferiens?
It is a rapid rising, twice beating wave in the systole of the pulse, felt in idiopathic hypertrophic subaortic stenosis and severe aortic incompetence with mitral stenosis.
What is considered significant weight loss according to the 2009 definition?
Weight loss more than 5% in 30 days; more than 7.5% in 60 days; more than 10% in 180 days.
What are common causes of vomiting?
Pregnancy, travel sickness, gastritis, peptic ulcer, and intracranial tumors.
What does coffee ground colored vomitus indicate?
Upper GI bleed due to blood coming in contact with gastric juice.
What is the grading scale for vomiting?
0 (none), 1 (one episode in 24 hours), 2 (2-5 episodes), 3 (>6 episodes), 4 (needs parenteral fluid/nutrition).
What does the patient's attitude in bed indicate?
It can indicate their condition; for example, a comatose patient is silent and immobile, while a patient with ureteric stones may be restless.
What conditions can elevate Jugular Venous Pressure?
Cardiac tamponade, right ventricular failure, tricuspid stenosis, increased blood volume, asthma, emphysema, SVC obstruction.
What defines hypertension?
Persistent raised systolic (above 140 mm Hg) or diastolic (above 90 mm Hg) BP.
What is considered a high fever?
A temperature of 39.4°C to 40.5°C (103°F to 105°F).
What causes the large facial features in acromegaly?
Increased growth hormone due to pituitary acidophilic adenoma.
What is a key feature of Myasthenia gravis?
Weakness of all muscles, particularly eyelids.
What causes Gilbert’s syndrome?
Altered bilirubin transport leading to an increase in unconjugated bilirubin.
What chromosomal abnormality is associated with Down’s syndrome?
Extra chromosome 21, totaling 47 chromosomes.
What is diarrhea defined as?
More than 3 stools per day.
How does renal edema typically present?
Initially in the eyelids and face, then generalizes to legs and ascites.
What causes pallor in a patient?
Anaemia, massive bleeding, shock, and anxiety.
What causes subcutaneous emphysema?
Traumatic injuries like rib fractures, laryngeal injury, or surgical procedures that trap air in the subcutaneous plane.
What is the significance of a black hairy tongue?
It is seen in fungal infections.
What does furring of the tongue indicate?
It is seen in smokers, stomatitis, and poor oral hygiene.
What is polycythaemia?
Excess of circulating red blood cells, giving a purple-red florid appearance.
What is the significance of measuring blood pressure (BP) in clinical examination?
BP provides insight into the general condition of the patient and varies with factors like emotion, exercise, and age.
What is a macule?
A flat alteration in skin color that is not raised; examples include capillary naevi and purpuric macules.
What is the definition of stature?
Stature is the total height from vertex to soles.
What are café au lait spots?
Coffee brown colored patches on the skin, typically more than 5 in number.
What is the normal angle from skin to nail fold in a healthy individual?
130 to 170 degrees.
What are the skin characteristics in scleroderma?
Progressively thickened, pale, waxy skin with reduced facial expressions.
What is the normal angle (Lovibond angle) between the nail and the skin?
130°-170°.
What is referred pain?
Pain felt at a distant site rather than at the site of the disease.
What is the cardinal sign of oedema?
Pitting on pressure.
What is Grade I in the grading of clubbing?
Softening and fluctuation of the nailbed.
What should be ensured during a physical examination?
It should be done in privacy, with limited clothing and in broad daylight.
What nail changes are associated with syringomyelia, leprosy, and tabes dorsalis?
Ribbing, brittleness, and falling of nails.
What is Caput medusae and what condition is it associated with?
Visible dilated veins radiating from the umbilicus, seen in portal hypertension.
What is the typical flow direction of veins in IVC obstruction?
From below upwards towards the axillary vein along inguinoaxillary vein.
What is dwarfism?
Height that is far less than normal for age and sex, typically below 4.5 feet.
What is the significance of a patient's posture?
Posture reflects the positional relationship of different body regions and can indicate specific diseases.
What is a papule?
A raised tiny nodule, usually a few mm in size, seen in conditions like measles and chickenpox.
What is tachypnoea?
Rapid breathing seen in conditions like fever, shock, and hypoxia.
What changes occur in the nail curvature during clubbing?
Both longitudinal and transverse curvatures are increased.
What is a common feature of uraemia and intestinal obstruction?
Dry brown tongue.
What are common nail changes seen in Raynaud’s disease?
Specific discolorations.
What are the typical features of Turner’s syndrome?
Short stature, webbed shoulders, and a widened neck.
What is crepitus?
A crackling or grating sensation felt on palpation of subcutaneous tissue, joint, or bone.
Where is oedema commonly observed in bedridden patients?
In the sacral region.
What is the importance of assessing mental status?
It is crucial in specific clinical situations like head injury, hepatic encephalopathy, and septic shock.
What are the grades of mental status?
Grade I: properly oriented; Grade II: conscious but disoriented; Grade III: drowsy; Grade IV: unconscious but responsive; Grade V: comatose.
What is a common cause of localized pigmentation during pregnancy?
Pigmentation around the areola and midline abdomen.
What is nausea?
The sensation of wanting to vomit, which may or may not lead to actual vomiting.
What is the correct procedure for inflating a blood pressure cuff?
Cuff should be inflated rapidly and deflated early and completely.
What is the significance of pulse in clinical examination?
It is an ideal indicator of severity of many diseases.
What is a wheal?
An elevated patch on the skin with a paler center, often associated with allergic conditions.
When does oedema become clinically evident?
When fluid accumulates more than 5 litres.
What are the components of a normal Jugular Venous Pulse (JVP)?
3 positive waves (a, c, v) and 2 negative waves (x, y).
Which nerves are involved in diaphragmatic irritation causing referred pain at the shoulder?
Phrenic nerve (C4, C5) and cutaneous supply (C4, C5).
What causes peripheral cyanosis?
Poor perfusion of peripheral vessels leading to reduced oxyhemoglobin in capillaries.
What is the grading scale for edema?
0: None; 1: Asymptomatic, no drug therapy; 2: Symptomatic, requires drug therapy; 3: Symptomatic, limited function, not responding to therapy; 4: Anasarca.
What is cyanosis and what causes it?
Blue/purple discoloration in skin and mucous membranes due to increased levels of reduced hemoglobin.
What is wasting and where is it typically observed?
Wasting is observed on the upper half of the body, often with edema in the lower half due to hypoproteinaemia.
What is pulsus paradoxus and in which conditions is it observed?
Pulsus paradoxus is a decrease in systolic pressure during inspiration by more than 10 mm Hg, seen in SVC obstruction, airway obstruction, asthma, and pericardial effusion.
What is a waterhammer pulse and what conditions is it associated with?
A waterhammer pulse is a large bounding pulse with a forcible jerk, associated with conditions like thyrotoxicosis, AV fistula, and aortic regurgitation.
What is the normal range for Jugular Venous Pressure?
3-4 cm of water.
What are the causes of jaundice?
Pre-hepatic (excess hemolysis), hepatic (liver dysfunction), and post-hepatic (obstruction).
What factors should be noted when assessing pulse?
Rate, rhythm, tension and force, character, and condition of arterial wall.
What is macroglossia?
Enlargement of the tongue, seen in conditions like lymphangioma and acromegaly.
How is pain graded using the Visual Analogue Scale (VAS)?
It is compared to a 10 cm line numbered 0 to 10, where 0 means no pain and 10 is the worst pain.
What causes bilateral engorgement of the external jugular vein?
Myocardial infarction, intravenous fluid infusion, or retrosternal goiter/thoracic outlet obstruction.
What causes crepitus in bursitis?
It is felt when the lining is rough or contains loose fibrinous particles.
How is joint crepitus assessed?
By passively moving the affected joint with one hand while placing the other hand over it.
What does a transverse groove in nails suggest?
It is suggestive of systemic illness or stress.
Where is jaundice best checked?
In the upper sclera, nailbed, ear lobule, nasal tip, and under surface of the tongue.
What are the recommended conditions for measuring blood pressure accurately?
The patient should rest for 5 minutes, avoid exertion or meals 30 minutes prior, and the arm should be positioned correctly.
How should pulse be counted for accuracy?
For a full one minute; counting for a few seconds and multiplying is incorrect.
Where is peripheral cyanosis typically checked?
In the nailbed, palm, toes, and tip of the nose.
What is the pathogenesis of clubbing related to hypoxia?
Hypoxia leads to opening up of deep arteriovenous fistulas, increasing perfusion of fingers and toes.
How can central cyanosis be confirmed?
By checking the tongue, nailbed, palms, and toes.
What characterizes malignant cachexia?
Emaciation, shallow pale face, loose wrinkled dry skin, loss of fat, and profound loss of appetite/weight/energy.
What should be done if blood pressure is higher by more than 10 mm Hg?
It should be analyzed carefully.
What are signs of protein deficiency?
Rough skin, brittle hair, and edema in feet.
What is the ideal position for a patient when measuring blood pressure?
The usual position is supine with the arm supported at heart level.
What is continuous fever?
Fever that persists throughout the day without fluctuating more than 1°C.