What are the major anatomical components of the nervous system?
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The brain, spinal cord, and peripheral nerves.
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What are the major anatomical components of the nervous system?
The brain, spinal cord, and peripheral nerves.
What role does the spinal cord play in the nervous system?
It transmits signals between the brain and the rest of the body.
What is a con of CT scanning?
Radiation exposure.
What is another drawback of CT scans?
Low resolution.
What is divergence in the context of neurons?
The ability of a neuron to send signals to multiple targets.
What is Nissl staining used for?
To visualize neurons in the primary visual cortex and olfactory bulbs.
What do oligodendrocytes do?
They produce myelin in the central nervous system.
What does Electroencephalography (EEG) measure?
Electrical activity of the brain.
How many genes are expressed only in the nervous system out of the total human genes?
6000 out of 20,000.
What is a disadvantage of MEG?
Low spatial resolution.
What is the function of tubulin in neurons?
Tubulin is a key component of microtubules, providing structural support and facilitating transport within the neuron.
What are scaffold proteins in neurons?
Scaffold proteins help organize and anchor various proteins at synapses, playing a role in synaptic signaling.
What type of potential is involved in the knee-jerk response?
Excitatory potential.
What does fMRI stand for?
Functional Magnetic Resonance Imaging.
What does fMRI measure?
Brain activity by detecting changes associated with blood flow.
What type of tumor is indicated in the fMRI of the patient?
Right frontal lobe glioma.
What is Electroencephalography (EEG)?
An electrophysiological monitoring method to record electrical activity of the brain.
What role do dendrites play in neuron function?
Dendrites receive signals from other neurons.
What is Magnetoencephalography (MEG)?
A functional neuroimaging technique for mapping brain activity by recording magnetic fields.
What is the myotatic reflex?
A reflex that helps maintain muscle tone and posture by responding to muscle stretch.
What does the knee-jerk reflex demonstrate?
The basic functioning of a reflex arc.
What does MRI stand for?
Magnetic Resonance Imaging.
What is the primary use of MRI?
To form pictures of the anatomy and physiological processes of the body.
What is the significance of tau in neurons?
Tau is a protein that stabilizes microtubules in axons, playing a crucial role in maintaining neuronal structure.
What does the dye cresyl violet stain?
RNA.
What is notable about the expression of a single gene in the human brain?
The locations and levels of expression are very diverse.
In the context of the recording, what do the horizontal and vertical axes represent?
Horizontal = time, Vertical = action potential.
What are the diverse morphologies mentioned in the text?
Different types of nerve cell shapes in the human nervous system.
What is the purpose of a cerebral angiogram?
To examine blood vessels in the brain for abnormalities using contrast material.
What is the primary function of neurons?
Specialization for long-distance electrical signal and intercellular communication via synapses.
What is the function of astrocytes?
They support and maintain the environment around neurons.
What is the knee-jerk response?
A simple reflex circuit.
What is the role of inhibition in the knee-jerk response?
To regulate the reflex action.
What are peripheral nerves responsible for?
Connecting the central nervous system to limbs and organs.
How do the components of the nervous system function together?
They work in a network to process sensory information and execute motor functions.
In which species was the single-unit electrophysiological recording conducted?
In a monkey.
What is the significance of the receptive field in sensory neurons?
It defines the specific area where stimuli can trigger a response.
How do neurons function in relation to each other?
Neurons do not function in isolation; they are organized into neural circuits.
What is the function of motor systems in the human nervous system?
They respond to information by generating movement.
What are the pros and cons of EEG?
Pros: non-invasive; Cons: low resolution.
What is the typical length of axons in many neurons of the human brain?
No more than a few millimeters long.
What does white matter refer to?
Axon tracts and commissures.
What are the sensory tracts of the dorsal spinal cord called?
Columns.
What is a major advantage of MEG?
Excellent temporal resolution.
How many genes are there in total in the human genome?
20,000 genes.
What role do genes play in the development and function of neurons?
They relate to cell division and the production of neurons.
What is convergence in the context of neurons?
The ability of a neuron to receive signals from multiple sources.
What role does myelin play in neuronal function?
It insulates axons to increase the speed of electrical signals.
What does Event Related Potential (ERP) measure?
The brain response that is the direct result of a specific sensory, cognitive, or motor event.
What does the term 'convergence' refer to in the context of neurons?
The process where multiple neurons connect to a single neuron.
What are the two divisions of the motor portion of the PNS?
Somatic motor division and visceral (autonomic) motor division.
What do efferent neurons do?
They carry motor commands away from the central nervous system.
Who refuted the reticular theory?
Santiago Ramón y Cajal.
What is computed tomography (CT scanning)?
A medical imaging modality that obtains tomographic images or slices from a series of two-dimensional X-ray images taken in different directions.
What do PET and SPECT require for imaging?
Radioactive probe injection.
What is a benefit of PET and SPECT imaging?
Good image contrast.
What does 'inhabit' refer to in the context of the myotatic reflex?
The inhibition of opposing muscle activity during the reflex.
What technique is MRI a medical application of?
Nuclear Magnetic Resonance (NMR).
What does the gray area in the fMRI image represent?
The location of the glioma in the brain.
What is injected into blood vessels during a cerebral angiogram?
Dye for contrast imaging.
What is the role of the axon in a neuron?
Specialized for relaying electrical signals over long distances.
What does the peripheral nervous system (PNS) include?
Sensory neurons that link sensory receptors with processing circuits in the CNS.
What is the function of microglia?
They act as the immune cells of the central nervous system.
What are commissures?
Tracts that cross the midline of the brain.
What reflex is associated with the neural circuits shown in the recording?
The myotatic reflex.
What is the function of dendrites in neurons?
To receive signals from other neurons.
What does 'excited' refer to in the context of the myotatic reflex?
The activation of motor neurons leading to muscle contraction.
What is the synaptic cleft?
The small gap between the presynaptic and postsynaptic neurons.
What is the significance of the myotatic reflex?
It helps in maintaining balance and posture by adjusting muscle tension.
Is EEG invasive or noninvasive?
Typically noninvasive, with electrodes placed along the scalp.
What are ganglia in the peripheral nervous system (PNS)?
Local accumulations of nerve cell bodies and supporting cells.
What are some advantages of MRI?
Safe, non-invasive, versatile, can change pulse sequences to image different tissues, metabolic profiling.
How long can axons travel?
A few hundred micrometers or more; some can be about a meter long.
What is gray matter?
Any accumulation of cell bodies and neutrophils in the brain and spinal cord.
Which technique combines the principles of MRI and EEG to measure brain activity?
Magnetoencephalography (MEG).
What technique did Cajal use to refute the reticular theory?
A staining technique discovered by Golgi.
What can altered (mutated) genes lead to?
Neurological and psychiatric disorders.
What are neural circuits?
Ensembles of neurons that process specific kinds of information.
What are afferent neurons?
Nerve cells that carry information from the periphery towards the brain or spinal cord.
What are efferent neurons?
Nerve cells that carry information away from the brain or spinal cord.
What do sensory systems do in the human nervous system?
They acquire and process information from the internal and external environment.
What type of cell is an oligodendrocyte?
A type of glial cell that produces myelin in the central nervous system.
What types of maps can EEG reveal?
Somatosensory and motor maps.
What color does a dark/deep chemical reaction produce in staining?
Brown.
What is Transcranial Magnetic Stimulation (TMS)?
A noninvasive form of brain stimulation using a changing magnetic field to induce electric current in the brain.
What is a limitation of TMS?
It is less precise.
What is the purpose of Single-Photon Emission Computed Tomography (SPECT)?
To visualize blood flow and activity in the brain.
What does extracellular recording measure in neurons?
The relative frequency and pattern of action potentials.
What are CT scans particularly useful for detecting?
Brain lesions where the damage has a different tissue density than normal brain tissue.
What is indicated by the term 'Excited' in the context of action potentials?
It refers to the activation of neurons leading to action potentials.
What method is used to stain cortical neurons in Figure 1.6?
Golgi method (silver salts).
What is the significance of glucose in fMRI?
It is related to brain activity and metabolism.
What is the purpose of intracellular injection of fluorescent dye?
To label retinal neurons.
What are examples of sensory systems?
The visual system and auditory system.
What are peripheral axons gathered into?
Bundles called nerves.
What comprises the central nervous system (CNS)?
The brain (cerebral hemispheres, diencephalon, cerebellum, and brainstem) and the spinal cord.
What are nodes of Ranvier?
Gaps in the myelin sheath that facilitate rapid signal transmission.
What is the significance of peripheral axons?
They are part of the peripheral nervous system and transmit signals to and from the central nervous system.
What is the estimated number of neurons in the human brain?
About 86 billion.
What is the primary function of the brain in the nervous system?
To process information and coordinate responses.
What type of recording is used to study the myotatic reflex?
Intracellular recording.
What is a synapse?
The junction between two neurons where communication occurs.
What is a pneumoencephalogram?
A medical procedure where cerebrospinal fluid (CSF) is drained and replaced with air, oxygen, or helium to enhance X-ray imaging of the brain.
What role do interneurons play in neural circuits?
They participate only in the local aspects of a circuit.
What is the function of cell bodies in neurons?
Cell bodies process signals received via dendrites.
What do associational systems mediate?
The most complex and least well-defined brain functions, such as memory and emotion.
What is the role of myelin?
To insulate axons and increase the speed of electrical signals.
Which imaging technique provides high-resolution images of brain structures using magnetic fields?
Magnetic Resonance Imaging (MRI).
What is the reticular theory in neurobiology?
An obsolete theory stating that everything in the nervous system is a single continuous network.
What is the neuron doctrine?
The correct description of the nervous system as made of discrete cells.
What is the role of actin in neurons?
Actin is involved in dendritic outgrowth and the formation of spines.
What is a receptive field of a neuron?
The region in sensory space where a specific stimulus elicits an action potential response.
What types of responses can sensory neurons have?
They can respond positively, negatively, or inhibit.
What type of neurons are stained using the Golgi method?
Purkinje cells.
How does MRI differ from CT or PET scans?
MRI does not involve X-rays or ionizing radiation.
What imaging technique uses X-rays to create detailed images of the brain?
Computerized Tomography (CT).
What does cortex refer to in the nervous system?
Sheet-like arrangements of nerve cells.
What does the number of targets innervated by a neuron represent?
Its divergence.
Who postulated the reticular theory?
Joseph von Gerlach in 1871.
What award did Golgi and Cajal receive in 1906?
The Nobel Prize in Physiology or Medicine.
What do post-synaptic receptors do?
Post-synaptic receptors receive neurotransmitters released from the presynaptic neuron, facilitating communication between neurons.
What does MRI use to generate images?
Strong magnetic fields, magnetic field gradients, and radio waves.
What are the two main components of a typical neuron?
An axon (signal output) and dendrites (signal input).
What are some disadvantages of MRI?
Takes longer, louder, and not suitable for patients with medical implants.
What potential does TMS have?
Diagnostic and therapeutic potential in the central nervous system for various disease states.
What are the main components of a neuron?
Axon, dendrites, and synapses.
Who popularized the reticular theory?
Camillo Golgi.
How is a pneumoencephalogram performed?
By draining CSF through a lumbar puncture and replacing it with gas.
What are the main types of glial cells?
Astrocytes, Oligodendrocytes, and Microglia.
What are Schwann cells?
Glial cells that envelop many peripheral nerves.
What are neurons specialized for?
Electrical signaling over long distances.
What do afferent neurons do?
They carry sensory information to the central nervous system.
What type of cells are astrocytes?
A type of glial cell.
What is the blood-brain barrier (BBB)?
A barrier that prevents certain substances from entering the brain.
What imaging method is used to visualize the brain and cerebral vasculature in older techniques?
X-ray imaging.
Which technique uses magnetic fields to stimulate nerve cells in the brain?
Transcranial Magnetic Stimulation (TMS).
What do the number of dendrites in a neuron indicate?
The degree of convergence of a neuron.
What is the role of glial cells?
Support the signaling functions of nerve cells.
What is the function of microglia cells?
Act as immune cells in the brain.
What is a nucleus in the context of the nervous system?
A local accumulation of neurons with similar connections and functions.
What are the specialized contacts through which neurons communicate?
Synapses.
What are tracts in the central nervous system (CNS)?
Gathered axons analogous to nerves in the PNS.
What type of cells are Schwann cells?
A type of glial cell.
What imaging technique detects brain activity by measuring changes in blood flow?
Positron Emission Tomography (PET).
What is the function of oligodendrocytes?
To produce myelin.
What was the contribution of Golgi and Cajal recognized by the Nobel Prize?
Their work on the structure of the nervous system.