What percentage of Motor Neurone Disease (MND) cases are sporadic?
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90%.
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What percentage of Motor Neurone Disease (MND) cases are sporadic?
90%.
What morphological changes occur in the spinal cord due to MND/ALS?
Degeneration of the ventral horns, ventral spinal roots, and corticospinal tracts.
What are the signs of Lower Motor Neuron (LMN) involvement?
Progressive muscle weakness, muscle atrophy, fasciculations, and hyporeflexia.
What is the primary pathogenesis of MND/ALS?
Progressive degeneration of Lower Motor Neurons (LMNs) and Upper Motor Neurons (UMNs) in the spinal cord.
Is there a known cure for MND?
No, there is currently no cure for MND.
What innervates skeletal muscles?
Lower Motor Neurons (LMNs) from the Ventral Spinal Root.
What are the signs of Upper Motor Neuron (UMN) involvement?
Spasticity, stiffness, rigidity, and hyperreflexia.
What happens to voluntary muscles in MND/ALS?
They are affected, leading to difficulties in walking, speaking, breathing, and swallowing.
What type of treatment is available for MND/ALS?
Supportive treatment, including ventilation and parenteral nutrition.
What are common clinical features of MND/ALS?
Progressive weakness, muscle wasting, fasciculations, spasticity, and hyperreflexia.
What is the prognosis for individuals diagnosed with MND?
The prognosis varies, but it generally leads to progressive disability.
What is the prognosis for MND/ALS?
It is incurable, with death typically occurring within 3 years.
What are common symptoms of MND?
Muscle weakness, difficulty speaking, and swallowing.
What is the primary effect of MND?
It affects the motor neurons in the brain and spinal cord.
What other neurodegenerative disease is associated with ALS?
Fronto-temporal dementia
