Gautam Biswas Forensic Medicine & Toxicology 3rd Edition_compressed (1)

Created by Ms. Ishita Mitra

p.1

In what cases is identification necessary for living persons?

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p.1

Criminal cases, civil cases, marriage, interchange of newborn babies, passport/license, impersonation, inheritance, absconding soldiers and criminals, insurance claim, missing persons, disputed sex.

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p.1
Identification in Living Persons

In what cases is identification necessary for living persons?

Criminal cases, civil cases, marriage, interchange of newborn babies, passport/license, impersonation, inheritance, absconding soldiers and criminals, insurance claim, missing persons, disputed sex.

p.2
Race and Religion in Identification

What are some religious markers used for identification?

Circumcision, sacred thread, caste marks, saris, vermilion, tattoo marks, nose ring aperture, and ear piercings.

p.9
Sex Determination from Skeletal Remains

What is the preauricular sulcus described as a characteristic of?

The female pelvis.

p.14
Estimation of Age from Teeth Beyond 25 Years

What is the eruption pattern of permanent teeth?

First molar: 6-7 years, Central incisor: 6-8 years, Lateral incisor: 7-9 years, First premolar: 9-11 years, Second premolar: 10-12 years, Canine: 11-12 years, Second molar: 12-14 years, Third molar: 17-25 years.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the most common presentation of Klinefelter syndrome in terms of karyotype?

47XXY.

p.3
Sex Determination and Disorders of Sexual Developm...

What is the difference between sex and gender?

Sex refers to biological characteristics, while gender refers to sociological constructs and social identity.

p.15
Estimation of age from teeth beyond 25 years

What is radiocarbon dating of tooth enamel used for?

It may give a precise estimation of an individual’s date of birth.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the cause of congenital adrenal hyperplasia (CAH) in females?

Excessive production of testosterone by the adrenal glands.

p.11
Sex Determination and Disorders of Sexual Developm...

What is the difference in the shape of the pelvic brim or inlet between the male and female pelvis?

The male pelvis has a heart-shaped pelvic brim, while the female pelvis has a circular or elliptical shaped pelvic brim.

p.11
Sex Determination and Disorders of Sexual Developm...

How does the pelvic cavity differ between the male and female pelvis?

The male pelvis has a conical, funnel-shaped pelvic cavity, while the female pelvis has a broad, round pelvic cavity.

p.12
Sex Determination from Skeletal Remains

How does the sciatic notch index differ between male and female sacrum?

For males, the index ranges from 4–5, and for females, it ranges from 5–6.

p.12
Sex Determination from Skeletal Remains

What is the corporobasal index for female sacrum?

Less than 42.

p.16
Race and Religion in Identification

What is the anomaly called 'taurodontism' and its association with race?

Taurodontism is an aberration of teeth characterized by elongated pulp chambers and apical displacement of roots, giving it a rectangular shape. It is commonly seen in Mongoloids.

p.2
Identification in Living Persons

What are the different characteristics used for racial identification?

Complexion, eye color, hair type, skull shape, indices of long bones, and other physical features.

p.5
Disorders of Sexual Development

What is the term used to encompass any condition where external genitalia are atypical in relation to chromosome and gonads?

Disorder of sexual development (DSD).

p.13
Age Determination from Teeth

What is the composition of teeth?

Teeth are composed of dentin covered on the crown by enamel and on the root by cementum, which is attached to the alveolar bone by the periodontal membrane.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the result of androgen insensitivity in genetically male individuals?

Failure to develop male characteristics and development as female.

p.13
Age Determination from Teeth

How many sets of teeth does each individual have?

Two sets: temporary/deciduous/milk teeth and permanent teeth.

p.10
Sex Determination from Skeletal Remains

How does the chin (symphysis menti) differ between male and female mandibles?

The male mandible has a square or U-shaped chin, while the female mandible has a rounded chin.

p.10
Sex Determination from Skeletal Remains

What is the difference in the angle of body with ramus between male and female mandibles?

The angle is less obtuse and prominent in the male mandible, while it is more obtuse and not prominent in the female mandible.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the most certain evidence of sex in living individuals?

Possession of ovaries in females, and testes in males.

p.7
Sex Determination and Disorders of Sexual Developm...

What are the risks associated with Klinefelter syndrome in men?

Autoimmune diseases, diabetes mellitus, leg ulcers, osteopenia, osteoporosis, tumors (breast and germ cells), gonadotroph adenoma, gonadotroph hyperplasia, liver adenoma, SLE, rheumatoid arthritis, and Sjögren syndrome.

p.12
Sex Determination from Skeletal Remains

How does the sacroiliac articulation differ between male and female sacrum?

In the male sacrum, it extends up to the 3rd segment, while in the female sacrum, it extends up to the 2–2½ segment.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the methods used for sex verification tests?

Physical morphology, nuclear sexing, gonadal biopsy, and gene-based tests.

p.16
Age Determination from Teeth

What is the first bone to ossify in the body and when does it occur?

The clavicle is the first bone to ossify, with a secondary center forming between 15–17 years and fusing by 20–22 years.

p.5
Identification in Living Persons

What is the name of the tiny, dark staining blob found in the nucleus of female cats?

Barr body.

p.13
Age Determination from Teeth

What are the parts of a tooth?

A tooth has a crown, neck, and a root embedded in the jaw bone.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the basic etiology of androgen insensitivity?

Mutation in the androgen receptor gene.

p.9
Sex Determination from Skeletal Remains

What is the Kimura’s Base-wing index used to determine?

The sex of human skeletal remains.

p.8
Sex Determination and Disorders of Sexual Developm...

What are the characteristics of individuals with complete androgen insensitivity syndrome?

Female external genitalia, normal size breasts, primary amenorrhea, and scanty or absent axillary and pubic hair.

p.14
Estimation of Age from Teeth Beyond 25 Years

What is the significance of the eruption of teeth in estimating age?

It is useful in estimating age up to 15 years.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the result of 5-alpha reductase deficiency in genetic males?

Ambiguous genitalia at birth.

p.6
Sex Determination and Disorders of Sexual Developm...

How is Klinefelter syndrome diagnosed?

Karyotyping using lymphocytes or fibroblasts, or by determining the presence of RNA for X-inactive-specific transcriptase (XIST) in peripheral blood leukocytes by polymerase chain reaction. Serum testosterone is low, and FSH, LH, and estradiol are elevated.

p.15
Estimation of age from teeth beyond 25 years

What are Gustafson's criteria for age estimation from teeth beyond 25 years?

They include attrition, periodontosis, secondary dentin, cementum apposition, root resorption, and root transparency.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the most common karyotype associated with Turner syndrome?

45XO.

p.16
Age Determination from Teeth

How is the degree of periodontosis estimated before a tooth is extracted?

By grinding the tooth down on glass slabs from both sides to about 1 mm, which allows estimation of transparency, then further grinding to about ¼ mm for microscopic examination.

p.12
Sex Determination from Skeletal Remains

How does the sacral index differ between male and female sacrum?

For males, it is less than 114, and for females, it is greater than 114.

p.4
Sex Determination and Disorders of Sexual Developm...

What is the Barr body in karyotypes?

It is the condensed, inactive, single X-chromosome found in the nuclei of somatic cells of most females and is the basis of sex determination tests.

p.1
Identification Data in Living and Dead Persons

What are the primary characteristics of identification in living and dead individuals?

Race, religion, sex, age, teeth, general development and stature, anthropometric measurements, fingerprints, lip prints, footprints, external peculiarities, hair, personal effects.

p.5
Sex Determination and Disorders of Sexual Developm...

What is the staining method used for the Y-chromosome that is seen as a bright fluorescent body?

Quinacrine dihydrochloride.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the most common sex chromosome disorder associated with male hypogonadism?

Klinefelter syndrome.

p.13
Age Determination from Teeth

What factors does the age of eruption of teeth depend upon?

Heredity, environment, nutrition, and endocrine factors.

p.13
Age Determination from Teeth

What are the differences between temporary and permanent teeth?

Temporary teeth are smaller, lighter, narrower, have a more constricted neck, and have smaller, more divergent roots compared to permanent teeth.

p.14
Age Determination from Teeth

What is the most commonly impacted tooth in the mouth?

The mandibular third molar.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the most common cause of death in adult women with Turner syndrome?

Cardiovascular disease.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the frequent circumstances where determination of sex has become necessary?

Sports, pre-employment, and sex-specific crimes.

p.16
Age Determination from Teeth

Which teeth are more suitable for age estimation and why?

Anterior teeth are more suitable than posterior teeth. Merit decreases from incisors to premolars, and molars are quite unsuitable.

p.16
Sex Determination from Skeletal Remains

How can sex determination be done using teeth?

By visual and microscopic examination, optical scanner and radiogrammetric measurements, identifying Y-chromosome in dental pulp tissue, and isolation of sex-specific banding patterns in DNA profiles of X and Y-chromosomes.

p.16
Identification in Living Persons

How can occupation and habits be determined from teeth?

Cobblers or tailors usually show notched upper incisors from wear and tear, while dark brown stains on the back of incisors are seen in 'cigarette smokers'.

p.13
Age Determination from Teeth

How can age be determined using dentition?

By using criteria like eruption and calcification of teeth, Stack’s method, Miles method, Boyde’s method, and Gustafson’s method.

p.4
Sex Determination and Disorders of Sexual Developm...

What is nuclear sexing?

It is a method of sexing cells used to determine sex in doubtful cases, decomposed and mutilated bodies, and fragmentary remains.

p.11
Sex Determination and Disorders of Sexual Developm...

What are the general appearance differences between the male and female pelvis?

The male pelvis is massive, rougher, and has prominent muscular markings, while the female pelvis is less massive, slender, smoother, and with less prominent muscular markings.

p.15
Estimation of age from teeth beyond 25 years

What is Miles' method for age estimation from teeth beyond 25 years?

It assesses the amount of wear on all three permanent molars at comparable rates and measures the thickness of enamel and dentin from neonatal line to determine age at death.

p.9
Age Determination from Teeth

What are some of the features utilized for age determination from skeletal remains?

Dental eruption, epiphyseal unions, pubic symphyseal morphology, cranial suture closures, mandibular and sacral changes, secondary sexual characters, and age-related degenerative conditions.

p.9
Sex Determination from Skeletal Remains

What are some differences between male and female skulls?

Differences include general appearance, forehead shape, cranial capacity, glabella prominence, and more.

p.6
Sex Determination and Disorders of Sexual Developm...

What are the clinical features of Klinefelter syndrome?

Delay in onset of puberty, gynecomastia at puberty, absence of axillary and pubic hair, eunuchoidism, tall stature, abnormal body proportions, firm and fibrotic testes, azoospermia, mental deficiency, and problems with coordination and social skills.

p.12
Sex Determination from Skeletal Remains

What is the difference in the inner curvature between the male and female sacrum?

The male sacrum is uniformly curved anteriorly, while the female sacrum is abruptly curved at the last two segments.

p.7
Sex Determination and Disorders of Sexual Developm...

What type of hypogonadism is seen in Klinefelter syndrome?

Hypergonadotropic hypogonadism.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the incidence of Turner syndrome?

1 in 2,500 newborns.

p.10
Sex Determination from Skeletal Remains

How do the muscular markings differ between male and female mandibles?

Muscular markings are prominent in the male mandible and not prominent in the female mandible.

p.2
Identification in Living Persons

What are the different indices of long bones used for racial identification?

Brachial index, crural index, humero-femoral index, and intermembral index.

p.9
Sex Determination from Skeletal Remains

What is the accuracy of sexing based on the entire skeleton from adult skeletal remains?

100%.

p.13
Age Determination from Teeth

What is the first radiographic evidence of tooth formation?

Formation of a bony crypt followed by mineralization of crown tips.

p.11
Sex Determination and Disorders of Sexual Developm...

How does the shape of the male pelvis differ from the female pelvis?

The male pelvis has a deep funnel shape, while the female pelvis has a flat bowl shape.

p.15
Estimation of age from teeth beyond 25 years

What is the chemical method for age estimation from teeth beyond 25 years?

It involves estimation of nitrogen content (increases with age), carbonate content (decreases with age), and concentration of ions—Cu, Se, and Fe (increases with age).

p.12
Sex Determination from Skeletal Remains

How does the breadth of the body of the 1st sacral vertebra differ between male and female sacrum?

In the male sacrum, it is more than the breadth of one side ala, while in the female sacrum, it is less than the breadth of one side ala.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the challenges in identifying biological sex in living individuals?

Intersex conditions, transvestism, transgender, transsexuals, concealed sex, and advanced decomposition.

p.16
Race and Religion in Identification

What is the significance of 'shovel-shaped' upper central incisors in race determination?

They can be found in most Mongoloids and Americans, indicating a racial determinant.

p.2
Identification in Living Persons

What are the three types of skull based on cephalic index (CI)?

Dolichocephalic, brachycephalic, mesaticephalic.

p.1
Corpus Delicti in Homicide Cases

What does 'corpus delicti' refer to in forensic medicine?

The principle that it must be proven that a crime has actually occurred before a person can be convicted of committing the crime.

p.1
Sex Determination and Disorders of Sexual Developm...

Why are sex, age, and stature considered primary characteristics of identification?

They are unaltered even after death.

p.13
Age Determination from Teeth

When does root mineralization begin in teeth?

Root mineralization does not begin until crown formation is complete.

p.11
Sex Determination and Disorders of Sexual Developm...

What is the difference in the size of the acetabulum between the male and female pelvis?

The male pelvis has a large acetabulum with a 52 mm diameter, while the female pelvis has a small acetabulum with a 46 mm diameter.

p.12
Sex Determination from Skeletal Remains

What are the differences in the general appearance of the male and female sacrum?

Male sacrum is larger, heavier, rough, and narrow, while the female sacrum is smaller, lighter, smooth, and broad.

p.11
Sex Determination and Disorders of Sexual Developm...

What is the difference in the greater sciatic notch between the male and female pelvis?

The male pelvis has a narrow, deep, and small greater sciatic notch, while the female pelvis has a broad, shallow, and large greater sciatic notch.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the highly probable evidence of sex in living individuals?

Possession of sexual structures, e.g. developed breasts and vagina in females, and male distribution of hair and penis in males.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the most common sex chromosome disorder associated with female hypogonadism?

Turner syndrome.

p.3
Sex Determination and Disorders of Sexual Developm...

What are the reasons for sex determination in the context of civil rights and legal matters?

To decide whether an individual can exercise certain civil rights extended to one sex only, and for deciding questions relating to legitimacy, divorce, paternity, marriage, impotence, rape, and affiliation.

p.6
Sex Determination and Disorders of Sexual Developm...

What are the clinical features of Turner syndrome?

Anatomically female, pass in external genitalia examination, but have false negative Barr body testing. This condition can be recognized at birth by lymphedema.

p.16
Age Determination from Teeth

What is the basis of the histological technique for age estimation from teeth?

It is based on the counting of incremental lines in dental cementum added to the average age of tooth eruption for the estimation of the age at death.

p.2
Identification in Living Persons

How is the cephalic index (CI) calculated?

CI = (Maximum transverse breadth of skull / Maximum anteroposterior length of skull) × 100.

p.9
Sex Determination from Skeletal Remains

What is the least useful bone for determining the sex of adult skeletal remains?

Sternum.

p.9
Sex Determination from Skeletal Remains

What is the accuracy of sexing based on the pelvis alone from adult skeletal remains?

95%.

p.14
Period of Mixed Dentition

What is the period of mixed dentition?

The duration from the eruption of the first permanent molar till before the eruption of the last permanent canine, when both temporary and permanent teeth are present in the jaw.

p.9
Sex Determination from Skeletal Remains

What is the chilotic line index used for?

Identifying the sex of human skeletal remains.

p.11
Sex Determination and Disorders of Sexual Developm...

How does the obturator foramen differ between the male and female pelvis?

The male pelvis has a large, oval obturator foramen with the base upwards, while the female pelvis has a small, triangular obturator foramen with the apex forwards.

p.15
Estimation of age from teeth beyond 25 years

What is the most reliable destructive method of dental age estimation?

Amino acid racemization.

p.12
Sex Determination from Skeletal Remains

What are the differences in the washburn/ischiopubic index for male and female sacrum?

For males, the index ranges from 73–94, and for females, it ranges from 91–115.

p.10
Sex Determination from Skeletal Remains

What is the difference in ramus flexure between male and female mandibles?

The male mandible has rearward angulation of the posterior border of ramus, while the female mandible has a straight ramus.

p.1
Identification in Living Persons

What is the definition of identification in forensic medicine?

The determination of the individuality of a person based on certain physical characteristics.

p.2
Identification in Living Persons

What are 'Mongolian spots' and how do they help in racial identification?

Hyperpigmented spots found over the lumbosacral region of infants, which occur in people of different races and help in racial identification.

p.5
Disorders of Sexual Development

What is the condition known as double-sex or bisexual, where both ovarian and testicular tissues are present?

Ovotesticular DSD (true hermaphroditism).

p.4
Sex Determination and Disorders of Sexual Developm...

What are some physical/morphological features used to determine sex?

General built, scalp hair, facial hair, pubic hair, Adam’s apple, shoulders, waist, trunk, thighs, breasts, uterus and vagina, penis, and gonads.

p.10
Sex Determination from Skeletal Remains

What are the general appearance differences between male and female mandibles?

Male mandible is larger and thicker, while the female mandible is smaller and thinner.

p.8
Sex Determination and Disorders of Sexual Developm...

What differentiates 5-alpha reductase deficiency from partial androgen insensitivity syndrome?

Normal production of testosterone and normal conversion to dihydrotestosterone (DHT).

p.10
Sex Determination from Skeletal Remains

How does the angle of mandible (gonion) differ between male and female mandibles?

The angle is everted in the male mandible and inverted in the female mandible.

p.12
Sex Determination from Skeletal Remains

What is the sternal index for male sacrum?

46.2.

p.1
Identification in Living Persons

What are the two types of identification mentioned in the text?

Complete (absolute) and Partial (incomplete).

p.4
Sex Determination and Disorders of Sexual Developm...

How is the sex of an individual differentiated based on testosterone levels?

For females, testosterone levels should be < 10 nmol/l, which is lower than the lower limit of normal for males.

p.14
Age Determination from Teeth

How are developmentally teeth divided into sets?

a. Super-added permanent teeth b. Successional permanent teeth.

p.5
Sex Determination and Disorders of Sexual Developm...

What is the staining method used for the X-chromosome that is seen as a bright yellow spot in nuclei?

Fluorescent Feulgen reaction using Acriflavin Schiff reagent.

p.14
Estimation of Age from Teeth Beyond 25 Years

What is the eruption pattern of deciduous teeth?

Central incisor: 6-8 months, Lateral incisor: 7-9 months, First molar: 12-14 months, Canine: 17-18 months, Second molar: 20-30 months.

p.7
Sex Determination and Disorders of Sexual Developm...

What are the clinical features of Turner syndrome?

Short stature, webbed neck, micrognathia, high-arched palate, ptosis with low-set ears, low hairline, widely spaced nipples, cubitus valgus, short fourth metacarpals, hyperconvex nails, lymphedema of hands and feet, pigmented nevi, keloid formation, learning disability, cardiovascular anomalies, renal abnormalities, increased urinary gonadotrophin exertion, sexual infantilism, high incidence of osteoporosis, type II diabetes.

p.11
Sex Determination and Disorders of Sexual Developm...

How does the subpubic angle differ between the male and female pelvis?

The male pelvis has a V-shaped, sharp angle with a 70°–75° angle, while the female pelvis has a U-shaped, rounded, and broader angle with a 90°–100° angle.

p.10
Sex Determination from Skeletal Remains

What is the difference in body height at symphysis between male and female mandibles?

The male mandible has greater body height at symphysis, while the female mandible has smaller body height at symphysis.

p.3
Identification in Living Persons

Why is sex determination important in the context of identification in living persons?

It is important in any chain of identity data and determination of the individuality of a person.

p.16
Age Determination from Teeth

How does aspartic acid racemization help in age estimation?

During the course of aging, L-forms of amino acids are transformed by racemization to D-forms. The extent of racemization of amino acids may be used to estimate the age.

p.9
Sex Determination from Skeletal Remains

What bones can be used to determine the sex of skeletal remains based on medullary index?

Tibia, humerus, ulna, and radius.

p.5
Disorders of Sexual Development

What is the term used to refer to a defect in gonad formation characterized by a progressive loss of primordial germ cells?

Gonadal dysgenesis.

p.4
Sex Determination and Disorders of Sexual Developm...

What is the purpose of histological examination in sex determination?

To identify the Barr body (sex chromatin) in the nuclei of somatic cells, which is the basis of sex determination tests.

p.8
Sex Determination and Disorders of Sexual Developm...

What is the most common form of male pseudohermaphroditism?

Complete androgen insensitivity syndrome (cAIS).

p.15
Estimation of age from teeth beyond 25 years

What is Gustafson's method for age estimation from teeth beyond 25 years?

It involves microscopic examination of longitudinal tooth sections to assess changes due to wear and tear, and is useful only for examining dead bodies or skeletal remains.

p.6
Sex Determination and Disorders of Sexual Developm...

What is the incidence of Klinefelter syndrome?

1 in 500; chances are more with increasing maternal age.

p.7
Sex Determination and Disorders of Sexual Developm...

What is the diagnosis for Turner syndrome?

Evaluation for childhood short stature, confirmation of hypogonadism in girls with high serum levels of FSH and LH, and a karyotype showing 45XO.

p.10
Sex Determination from Skeletal Remains

How does the ascending ramus differ between male and female mandibles?

The male mandible has greater breadth in the ascending ramus, while the female mandible has smaller breadth.

p.16
Age Determination from Teeth

What is the method used to determine the year of tooth formation?

Radiocarbon analysis of tooth enamel based on levels of radiocarbon present in tooth enamel.

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