20-50 um in diameter.
20-60 um in diameter.
Fine dustlike azurophilic granules with a groundglass appearance.
9-15 um in diameter.
No or Few.
Kupffer cells.
Moderate to abundant amount, giving a decreased NC ratio.
In two forms: segmented or band shape.
Light blue to purple.
Phagocytosis and destruction of foreign material and microorganisms.
Blue-gray.
40-120 um in diameter.
Bacterial pathogens.
The process of monocyte production.
Segmented neutrophils.
None.
Yes, they are larger.
Pinkish blue in color, very fine and diffusely granular, and usually has an irregular peripheral border.
Coarse clumps of granules aggregating into little bundles, which bud off from the periphery to become platelets.
Small in comparison to cell size, multiple nuclei may be visible, and chromatin is coarser than the previous stage.
Arylsulfatase, Peroxidase, Acid phosphatase, Histamine, Heparin, Eosinophulic chemotactic factor-A, Peroxidase.
It is round, oval, or may be kidney-shaped, with a fine chromatin pattern and multiple nucleoli that generally stain blue.
Less than 1:1.
In the Golgi region.
1-4 um in diameter.
30 hours.
2 to 5 lobes connected by thin nuclear filament.
Lysozyme, Lactoferrin, Collagenase, Plasminogen activator, Aminopeptidase.
Macrophage, dendritic cell, or an osteoclast.
Phagocytosis and cytokine production.
30 hours.
Transcobalamin I or R binder protein.
Pale blue to basophilic, full of primary azurophilic granules.
12-18 um in diameter.
A few to many large blue to reddish purple staining nonspecific (primary) granules.
Moderate amount, may contain few patches of blue, and few to moderate number of nonspecific granules.
9-15 um in diameter.
Phagocytosis by neutrophils.
9-15 um in diameter.
Nongranular, appears smooth, and is moderate to dark blue in color.
It has a small amount in relation to the rest of the cell, is usually moderate blue in color, and has a smooth and usually nongranular texture.
8 to 10 μm in diameter.
Round or slightly oval, occupying about four-fifths of the cell, with an NC ratio of 4:1 and an extremely fine chromatin pattern, appearing reddish purple in color.
15-21 um in diameter.
10-16 um in diameter.
Routine maintenance and clearance of cellular debris.
T cells, B cells, and NK cells.
Usually nongranular, but may contain occasional azurophilic granules.
The process of lymphocyte production.
Pinkish or lighter staining.
10-18 um in diameter.
Production of antibodies by lymphocytes and plasma cells.
Phagocytosis.
Major Basic Protein (MBP), Phospolipase, Cathepsin, Eosinophil Cationic Protein, Eosinophil derived neurotoxin, Eosinophil protein X.
Generation of NETs (NETosis).
Multiple nuclei.
12-20 um in diameter.
They are capable of rearranging antigen receptor gene segments to produce a wide variety of antibodies and surface receptors.
10-15 um in diameter.
Outside the bone marrow.
Moderate to abundant amount, with a decreased NC ratio and few nonspecific granules.
They can destroy red blood cells (RBCs).
Yes, they are water soluble and tend to wash out when stained.
Alpha & Dense Granules.
The process of producing megakaryocytes, the precursor cells of platelets.
Mediating immunity.
Pink to rose-violet.
Dirty orange to blue.
14-18 um in diameter.
30-90 um in diameter.
Different patterns of chemokine receptors.
15-20 um in diameter.
Lymphocytes are not end cells, they are resting cells and undergo mitosis to produce memory and effector cells when stimulated.
Varying shades of blue, usually darker than the myeloblast, may have small, blunt pseudopods, and nongranular.
Lymphocytes recirculate from the blood to the tissues and back to the blood.
It may be the same size or smaller.
Thrombopoietin (TPO).
Moderate to dark blue.
The kidney.
Blue.
Tertiary granules (gelatinase granules).
No.
They ignore self-antigens.
It becomes coarser and more condensed.
Attacking foreign organisms or cells.
Aggregated.
Alveolar macrophages.
Langerhans cells.
Osteoclasts.
The chromatin pattern is somewhat coarse, and it is round or oval in shape.
Nitric oxide.
As antigen-presenting cells (APCs).
Elongated or band-shaped, deeply indented from the metamyelocyte stage.
12 to 16 μm in diameter.
At the site of infection or tissue damage, destruction of senescent RBCs, and maintenance of a storage pool of iron for erythropoiesis.
Ovoid or round.
Double nuclei.
Adhesion and Aggregation.
Azurophilic granules.
The presence of many fine azurophilic granules.
Plasma cells and plasmacytoid cells.
Lysozyme, Acetyltransferase, CD11b/CD18, ALP, Vesicle-associated membrane-2, CD10, CD13, CD14, CD16, Cytochrome b 558, Complement receptor-1.
Peritoneal macrophages.
In the reproductive organs.
It is more abundant than the previous stage.
Oval, may have single fold or fissure, with 1 to 5 nucleoli and a fine chromatin pattern.
10 to 12 μm in diameter.
T and B lymphocytes.
Moderately basophilic to blue-gray and nongranular.
Few.
To prevent loss of blood by forming platelet-plugs.
Round or oval.
4:1 to 3:1.
Producing antibodies.
Due to the presence of pseudopods.
Hematogones.
Collagenase, Gelatinase, Lactoferrin, Neutrophil gelatinase-associated lipocalin, Transcobalamin I.
To secondary lymphoid organs or in the circulating blood.
CD56, CD16, CD3, and CD7.
Few nonspecific granules and a full complement of specific granules.
Reddish-orange.
It becomes more coarse.
2 lobes.
Slightly pink to colorless.
At sites of infection.
Dark-purple to blue-black.
Small, specific (secondary) granules.
Indented or kidney shaped, with coarse and clumped chromatin pattern that stains dark purple.
14-20 um in diameter.
Blue-gray.
Tertiary granules are another type of granules found in neutrophils.
Vacuoles.
Yes.
Littoral cells.
Dendritic cells.
Coarse, clumped chromatin pattern.
Adaptive Immunity.
Light blue purple in color, with fine, lacey chromatin and 1 to 2 nucleoli.
Oval or round.
Reticulated or Stress platelets.
Two or more nuclei.
In the bone marrow as pro-B, pre-B, and immature B cells.
Myeloperoxidase, Acid ß-glycerophosphate, Cathepsins, Defensins, Elastase, Proteinase 3, ß2-Microglobulin.
No.
Intestinal macrophages.
Type A cell.
It occupies half or more of the cell, with an NC ratio of 3:1 to 2:1, and has an oval or round shape with a coarser chromatin pattern.
They produce memory for reexposure.
No.
Specific granules.
It may be eccentric.
Four or more nuclei.
Microglia.
Kills target cells, also known as cytotoxic T lymphocytes.
Renal macrophages.
It is round, oval, or slightly indented, with a more clumped chromatin pattern and may contain 1 to 2 nucleoli.
Protein synthesis.
Generally unsegmented or bilobed and does not appear as coarse as in the neutrophil or eosinophil.
Numerous.
No nucleoli present.
Secretory vesicles.
Round, kidney-shaped, or slightly lobulated (brainlike convulotion).
CD4 and CD8.
Large granular lymphocytes.
In the thymus as pro-T, pre-T, and immature T cells.
T H 1 – intracellular pathogens, T H 2 – extracellular parasites (helminths), asthma, T H 17- extracellular bacteria and fungi.
Killing virus-infected cells and tumor cells.
